Propagation of Plasma L-Phenylalanine Concentration Fluctuations to the Neurovascular Unit in Phenylketonuria: An in silico Study

Phenylketonuria (PKU) is an inherited metabolic disease characterized by abnormally high concentrations of the essential amino acid L-phenylalanine (Phe) in blood plasma caused by reduced activity of phenylalanine hydroxylase (PAH). While numerous studies have shown association between high plasma P...

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Publicat a:Front Physiol
Autors principals: Taslimifar, Mehdi, Buoso, Stefano, Verrey, Francois, Kurtcuoglu, Vartan
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Physiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454150/
https://ncbi.nlm.nih.gov/pubmed/31105574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00360
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