S-Sulfocysteine Induces Seizure-Like Behaviors in Zebrafish

Sulfite is a neurotoxin, which is detoxified by the molybdenum cofactor (Moco)-dependent enzyme sulfite oxidase (SOX). In humans, SOX deficiency causes the formation of the glutamate analog S-Sulfocysteine (SSC) resulting in a constant overstimulation of ionotropic glutamatergic receptors. Overstimu...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Plate, Jennifer, Sassen, Wiebke A., Hassan, Ahmed H., Lehne, Franziska, Köster, Reinhard W., Kruse, Tobias
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454129/
https://ncbi.nlm.nih.gov/pubmed/31001109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00122
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