CACNA2D3 Enhances the Chemosensitivity of Esophageal Squamous Cell Carcinoma to Cisplatin via Inducing Ca(2+)-Mediated Apoptosis and Suppressing PI3K/Akt Pathways

Resistance to platinum-based combination chemotherapy is the main cause of poor prognosis in patients with advanced esophageal squamous cell carcinoma (ESCC). Previously, we showed that CACNA2D3 (voltage-dependent subunit alpha 2 delta 3 of a calcium channel complex) was significantly downregulated...

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Vydáno v:Front Oncol
Hlavní autoři: Nie, Changjun, Qin, Xiaohui, Li, Xiaoyan, Tian, Baoqing, Zhao, Ying, Jin, Yuan, Li, Yadan, Wang, Qiang, Zeng, Dingyuan, Hong, An, Chen, Xiaojia
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454090/
https://ncbi.nlm.nih.gov/pubmed/31001468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00185
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