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Immunodominance and Antigenic Variation of Influenza Virus Hemagglutinin: Implications for Design of Universal Vaccine Immunogens

Influenza viruses routinely acquire mutations in their hemagglutinin (HA) and neuraminidase (NA) glycoproteins that abrogate binding of pre-existing antibodies in a process known as antigenic drift. Most human antibodies against HA and NA are directed against epitopes that are hypervariable and not...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Infect Dis
Κύριοι συγγραφείς: Zost, Seth J, Wu, Nicholas C, Hensley, Scott E, Wilson, Ian A
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Oxford University Press 2019
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452323/
https://ncbi.nlm.nih.gov/pubmed/30535315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy696
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