Eculizumab prevents thrombotic microangiopathy in patients with atypical haemolytic uraemic syndrome in a long-term observational study

BACKGROUND: Eculizumab, a terminal complement inhibitor, is approved for atypical haemolytic uraemic syndrome (aHUS) to inhibit complement-mediated thrombotic microangiopathy (TMA). METHODS: In five parent studies, eculizumab effectively prevented TMA and improved renal and haematologic outcomes in...

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Veröffentlicht in:Clin Kidney J
Hauptverfasser: Menne, Jan, Delmas, Yahsou, Fakhouri, Fadi, Kincaid, John F, Licht, Christoph, Minetti, Enrico E, Mix, Chris, Provôt, François, Rondeau, Eric, Sheerin, Neil S, Wang, Jimmy, Weekers, Laurent E, Greenbaum, Larry A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Atypical Hemolytic Uremic Syndrome
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452204/
https://ncbi.nlm.nih.gov/pubmed/30976396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ckj/sfy035
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