Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate

Beta-catenin (CTNNB1) directs ectodermal appendage spacing by activating ectodysplasin A receptor (EDAR) transcription, but whether CTNNB1 acts by a similar mechanism in the prostate, an endoderm-derived tissue, is unclear. Here we examined the expression, function, and CTNNB1 dependence of the EDAR...

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Bibliographic Details
Published in:Biol Open
Main Authors: Wegner, Kyle A., Mehta, Vatsal, Johansson, Jeanette A., Mueller, Brett R., Keil, Kimberly P., Abler, Lisa L., Marker, Paul C., Taketo, M. Mark, Headon, Denis J., Vezina, Chad M.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451354/
https://ncbi.nlm.nih.gov/pubmed/30745437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.037945
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