The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair

P53-binding protein 1 (53BP1) mediates DNA repair pathway choice and promotes checkpoint activation. Chromatin marks induced by DNA double-strand breaks and recognized by 53BP1 enable focal accumulation of this multifunctional repair factor at damaged chromatin. Here, we unveil an additional level o...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Salvador Moreno, Naike, Liu, Jing, Haas, Karen M, Parker, Laurie L, Chakraborty, Chaitali, Kron, Stephen J, Hodges, Kurt, Miller, Lance D, Langefeld, Carl, Robinson, Paul J, Lelièvre, Sophie A, Vidi, Pierre-Alexandre
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
NAR Breakthrough Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451129/
https://ncbi.nlm.nih.gov/pubmed/30812030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz138
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