Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells

G-quadruplex ligands exert their antiproliferative effects through telomere-dependent and telomere-independent mechanisms, but the inter-relationships among autophagy, cell growth arrest and cell death induced by these ligands remain largely unexplored. Here, we demonstrate that the G-quadruplex lig...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Beauvarlet, Jennifer, Bensadoun, Paul, Darbo, Elodie, Labrunie, Gaelle, Rousseau, Benoît, Richard, Elodie, Draskovic, Irena, Londono-Vallejo, Arturo, Dupuy, Jean-William, Nath Das, Rabindra, Guédin, Aurore, Robert, Guillaume, Orange, Francois, Croce, Sabrina, Valesco, Valerie, Soubeyran, Pierre, Ryan, Kevin M, Mergny, Jean-Louis, Djavaheri-Mergny, Mojgan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Chemical Biology and Nucleic Acid Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451122/
https://ncbi.nlm.nih.gov/pubmed/30759257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz095
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