Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells

The 78-kDa glucose-regulated protein (GRP78) is an ubiquitously expressed endoplasmic reticulum chaperone, with a central role in maintaining protein homeostasis. Recently, an alternative role for GRP78 under stress conditions has been proposed, with stress-induced extracellular secretion and transl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Vig, Saurabh, Buitinga, Mijke, Rondas, Dieter, Crèvecoeur, Inne, van Zandvoort, Marc, Waelkens, Etienne, Eizirik, Decio L., Gysemans, Conny, Baatsen, Pieter, Mathieu, Chantal, Overbergh, Lut
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450900/
https://ncbi.nlm.nih.gov/pubmed/30952835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1518-0
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