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Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains

Dystroglycan (DG) is an adhesion complex that links the cytoskeleton to the surrounding extracellular matrix in skeletal muscle and a wide variety of other tissues. It is composed of a highly glycosylated extracellular α-DG associated noncovalently with a transmembrane β-DG whose cytodomain interact...

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Publié dans:Front Mol Biosci
Auteurs principaux: Dempsey, Christopher E., Bigotti, Maria Giulia, Adams, Josephine C., Brancaccio, Andrea
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450144/
https://ncbi.nlm.nih.gov/pubmed/30984766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00018
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