Prime-Boost Immunizations with DNA, Modified Vaccinia Virus Ankara, and Protein-Based Vaccines Elicit Robust HIV-1 Tier 2 Neutralizing Antibodies against the CAP256 Superinfecting Virus

A vaccine regimen that elicits broadly neutralizing antibodies (bNAbs) is a major goal in HIV-1 vaccine research. In this study, we assessed the immunogenicity of the CAP256 superinfecting viral envelope (CAP256 SU) protein delivered by modified vaccinia virus Ankara (MVA) and DNA vaccines in differ...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: van Diepen, Michiel T., Chapman, Rosamund, Douglass, Nicola, Galant, Shireen, Moore, Penny L., Margolin, Emmanuel, Ximba, Phindile, Morris, Lynn, Rybicki, Edward P., Williamson, Anna-Lise
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450106/
https://ncbi.nlm.nih.gov/pubmed/30760570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02155-18
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