Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

BACKGROUND: Internal tandem duplications (ITD) within the juxtamembrane domain of FMS-like tyrosine kinase 3 (FLT3) represent a poor prognostic indicator in acute myeloid leukemia (AML). Therapeutic benefits of tyrosine kinase inhibitors, such as sorafenib, are limited due to the emergence of drug r...

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Detalhes bibliográficos
Publicado no:Cancer Commun (Lond)
Main Authors: You, Xin, Jiang, Weiye, Lu, Wenhua, Zhang, Hui, Yu, Tiantian, Tian, Jingyu, Wen, Shijun, Garcia-Manero, Guillermo, Huang, Peng, Hu, Yumin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449955/
https://ncbi.nlm.nih.gov/pubmed/30947742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40880-019-0362-z
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