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Improving protein function prediction using protein sequence and GO-term similarities

MOTIVATION: Most automatic functional annotation methods assign Gene Ontology (GO) terms to proteins based on annotations of highly similar proteins. We advocate that proteins that are less similar are still informative. Also, despite their simplicity and structure, GO terms seem to be hard for comp...

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Vydáno v:Bioinformatics
Hlavní autoři: Makrodimitris, Stavros, van Ham, Roeland C H J, Reinders, Marcel J T
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449755/
https://ncbi.nlm.nih.gov/pubmed/30169569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty751
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