Glucose-dependent Insulinotropic Polypeptide (GIP) Resistance and β-cell Dysfunction Contribute to Hyperglycaemia in Acromegaly

Impaired insulin sensitivity (IS) and β-cell dysfunction result in hyperglycaemia in patients of acromegaly. However, alterations in incretins and their impact on glucose-insulin homeostasis in these patients still remain elusive. Twenty patients of active acromegaly (10 each, with and without diabe...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Shekhawat, Vikram Singh, Bhansali, Shobhit, Dutta, Pinaki, Mukherjee, Kanchan Kumar, Vaiphei, Kim, Kochhar, Rakesh, Sinha, Saroj K., Sachdeva, Naresh, Kurpad, Anura V., Bhat, Kishor, Mudaliar, Sunder, Bhansali, Anil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449401/
https://ncbi.nlm.nih.gov/pubmed/30948746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41887-7
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