miR-195 Regulates Metabolism in Failing Myocardium via Alterations in SIRT3 Expression and Mitochondrial Protein Acetylation

BACKGROUND: Heart failure (HF) leads to mitochondrial dysfunction and metabolic abnormalities of the failing myocardium coupled with an energy-depleted state and cardiac remodeling. The mitochondrial deacetylase sirtuin 3 (SIRT3) plays a pivotal role in the maintenance of mitochondrial function thro...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Zhang, Xiaokan, Ji, Ruiping, Liao, Xianghai, Castillero, Estibaliz, Kennel, Peter J., Brunjes, Danielle L., Franz, Marcus, Möbius-Winkler, Sven, Drosatos, Konstantinos, George, Isaac, Chen, Emily I., Colombo, Paolo. C., Schulze, P. Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449058/
https://ncbi.nlm.nih.gov/pubmed/29330215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.030486
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