Synergistic activation of pro-inflammatory type-2 CD8(+) T lymphocytes by lipid mediators in severe eosinophilic asthma

Human type-2 CD8(+) T-cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia - a phenotype associated with high exacerbation risk and responsiveness to type-2 cytokine-targeted therapi...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Hilvering, B, Hinks, TSC, Stöger, L, Marchi, E, Salimi, M, Shrimanker, R, Liu, W, Chen, W, Luo, J, Go, S, Powell, T, Cane, J, Thulborn, S, Kurioka, A, Leng, T, Matthews, J, Connolly, C, Borg, C, Bafadhel, M, Willberg, CB, Ramasamy, A, Djukanović, R, Ogg, G, Pavord, ID, Klenerman, P, Xue, L
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448764/
https://ncbi.nlm.nih.gov/pubmed/29907870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-018-0049-9
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