Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis

Expression of non-native transcriptional activators may be a powerful general method to activate secondary metabolites biosynthetic pathways. PAS-LuxR regulators, whose archetype is PimM, activate the biosynthesis of polyene macrolide antifungals and other antibiotics, and have been shown to be func...

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Udgivet i:Front Microbiol
Main Authors: Martínez-Burgo, Yolanda, Santos-Aberturas, Javier, Rodríguez-García, Antonio, Barreales, Eva G., Tormo, José Rubén, Truman, Andrew W., Reyes, Fernando, Aparicio, Jesús F., Liras, Paloma
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448028/
https://ncbi.nlm.nih.gov/pubmed/30984130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00580
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