NKG2A is a NK cell exhaustion checkpoint for HCV persistence

Exhaustion of cytotoxic effector natural killer (NK) and CD8(+) T cells have important functions in the establishment of persistent viral infections, but how exhaustion is induced during chronic hepatitis C virus (HCV) infection remains poorly defined. Here we show, using the humanized C/O(Tg) mice...

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Publicado no:Nat Commun
Main Authors: Zhang, Chao, Wang, Xiao-mei, Li, Shu-ran, Twelkmeyer, Trix, Wang, Wei-hong, Zhang, Sheng-yuan, Wang, Shu-feng, Chen, Ji-zheng, Jin, Xia, Wu, Yu-zhang, Chen, Xin-wen, Wang, Sheng-dian, Niu, Jun-qi, Chen, Hai-rong, Tang, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447531/
https://ncbi.nlm.nih.gov/pubmed/30944315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09212-y
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