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Neuron type-specific loss of CDKL5 leads to alterations in mTOR signaling and synaptic markers

CDKL5 disorder is a devastating neurodevelopmental disorder associated with epilepsy, developmental retardation, autism and related phenotypes. Mutations in the CDKL5 gene, encoding CDKL5, have been identified in this disorder. CDKL5 is a protein with homology to the serine-threonine kinases and inc...

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Detalhes bibliográficos
Publicado no:Mol Neurobiol
Main Authors: Schroeder, Ethan, Yuan, Li, Seong, Eunju, Ligon, Cheryl, DeKorver, Nicholas, Gurumurthy, C.B., Arikkath, Jyothi
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447488/
https://ncbi.nlm.nih.gov/pubmed/30288694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1346-8
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