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Pharmacological modulation of endogenous opioid activity to attenuate neuropathic pain in rats
We previously showed that spinal mGluR(1) signaling suppresses or facilitates (depending on stage of estrous cycle) analgesic responsiveness to intrathecal endomorphin 2 (EM2), a highly mu-opioid receptor (MOR)-selective endogenous opioid. Spinal EM2 antinociception is suppressed during diestrus by...
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| Publicado en: | J Pain |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6447302/ https://ncbi.nlm.nih.gov/pubmed/30366152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2018.10.003 |
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