Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5

Chronic consumption of high fat diets (HFDs), rich in saturated fatty acids (SatFAs) like palmitic acid (PA), is associated with the development of obesity and obesity-related metabolic diseases such as type II diabetes mellitus (T2DM). Previous studies indicate that PA accumulates in the hypothalam...

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Gepubliceerd in:Front Endocrinol (Lausanne)
Hoofdauteurs: Hernández-Cáceres, María Paz, Toledo-Valenzuela, Lilian, Díaz-Castro, Francisco, Ávalos, Yenniffer, Burgos, Paulina, Narro, Carla, Peña-Oyarzun, Daniel, Espinoza-Caicedo, Jasson, Cifuentes-Araneda, Flavia, Navarro-Aguad, Fernanda, Riquelme, Cecilia, Troncoso, Rodrigo, Criollo, Alfredo, Morselli, Eugenia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2019
Onderwerpen:
Endocrinology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446982/
https://ncbi.nlm.nih.gov/pubmed/30972025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2019.00176
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