The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome

Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly pop...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Oncol
Hauptverfasser: McBride, Amanda, Houtmann, Sarah, Wilde, Lindsay, Vigil, Carlos, Eischen, Christine M., Kasner, Margaret, Palmisiano, Neil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445951/
https://ncbi.nlm.nih.gov/pubmed/30972300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00192
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