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Use of Mortality as an Endpoint in Noninferiority Trials May Lead to Ethically Problematic Conclusions
BACKGROUND: Noninferiority trials are becoming more common. Their design often requires investigators to “trade” a secondary benefit for efficacy. Use of mortality as an outcome of interest leads to important ethical conflicts whereby researchers must establish a minimal clinically important differe...
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| Publicado no: | J Gen Intern Med |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6445912/ https://ncbi.nlm.nih.gov/pubmed/30756306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11606-018-4813-z |
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