Life-long reduction in myomiR expression does not adversely affect skeletal muscle morphology

We generated an inducible, skeletal muscle-specific Dicer knockout mouse to deplete microRNAs in adult skeletal muscle. Following tamoxifen treatment, Dicer mRNA expression was significantly decreased by 87%. Wild-type (WT) and Dicer knockout (KO) mice were subjected to either synergist ablation or...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Vechetti, Ivan J., Wen, Yuan, Chaillou, Thomas, Murach, Kevin A., Alimov, Alexander P., Figueiredo, Vandre C., Dal-Pai-Silva, Maeli, McCarthy, John J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445125/
https://ncbi.nlm.nih.gov/pubmed/30940834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41476-8
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