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A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence

Enterovirus A71 (EV-A71) is an emerging pathogen in the Enterovirus A species group. EV-A71 causes hand, foot and mouth disease (HFMD), with virulent variants exhibiting polio-like acute flaccid paralysis and other central nervous system manifestations. We analysed all enterovirus A71 complete genom...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Roberts, Ryan, Yee, Pinn Tsin Isabel, Mujawar, Shama, Lahiri, Chandrajit, Poh, Chit Laa, Gatherer, Derek
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443798/
https://ncbi.nlm.nih.gov/pubmed/30931960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41662-8
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