A Low Crizotinib Concentration in the Cerebrospinal Fluid Causes Ineffective Treatment of Anaplastic Lymphoma Kinase-positive Non-small Cell Lung Cancer with Carcinomatous Meningitis

The central nervous system is a common site of relapse in patients receiving crizotinib, which is presumed to be associated with the low concentration of crizotinib in the cerebrospinal fluid (CSF). Our patient received surgical treatment for anaplastic lymphoma kinase-positive stage IIA lung adenoc...

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Bibliographic Details
Published in:Intern Med
Main Authors: Okimoto, Tamio, Tsubata, Yukari, Hotta, Takamasa, Hamaguchi, Megumi, Nakao, Mika, Hamaguchi, Shun-ichi, Hamada, Akinobu, Isobe, Takeshi
Format: Artigo
Language:Inglês
Published: The Japanese Society of Internal Medicine 2018
Subjects:
Case Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443566/
https://ncbi.nlm.nih.gov/pubmed/30333394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2169/internalmedicine.1072-18
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