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Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons
Cortical hyperexcitability is a hallmark of fragile X syndrome (FXS). In the Fmr1 knockout (KO) mouse model of FXS, cortical hyperexcitability is linked to sensory hypersensitivity and seizure susceptibility. It remains unclear why homeostatic mechanisms fail to prevent such activity. Homeostatic in...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6443253/ https://ncbi.nlm.nih.gov/pubmed/30726724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.01.035 |
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