Taurine transporter (TauT) deficiency impairs ammonia detoxification in mouse liver

Hepatic ammonia handling was analyzed in taurine transporter (TauT) KO mice. Surprisingly, hyperammonemia was present at an age of 3 and 12 months despite normal tissue integrity. This was accompanied by cerebral RNA oxidation. As shown in liver perfusion experiments, glutamine production from ammon...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Qvartskhava, Natalia, Jin, Cheng Jun, Buschmann, Tobias, Albrecht, Ute, Bode, Johannes Georg, Monhasery, Niloufar, Oenarto, Jessica, Bidmon, Hans Jürgen, Görg, Boris, Häussinger, Dieter
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442586/
https://ncbi.nlm.nih.gov/pubmed/30862735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813100116
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