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SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs
The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC(50) values were found to be in the micromolar to submicromolar range. T...
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| 發表在: | J Enzyme Inhib Med Chem |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6442233/ https://ncbi.nlm.nih.gov/pubmed/30915862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1593158 |
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