Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation

ER protein 57 (ERp57), a thiol isomerase secreted from vascular cells, is essential for complete thrombus formation in vivo, but other extracellular ERp57 functions remain unexplored. Here, we employed a kinetic substrate-trapping approach to identify extracellular protein substrates of ERp57 in pla...

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Publicat a:J Biol Chem
Autors principals: Eriksson, Oskar, Chiu, Joyce, Hogg, Philip J., Atkinson, John P., Liszewski, M. Kathryn, Flaumenhaft, Robert, Furie, Bruce
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442054/
https://ncbi.nlm.nih.gov/pubmed/30670593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006792
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