Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

Protein kinase A (PKA), the main effector of cAMP in eukaryotes, is a paradigm for the mechanisms of ligand-dependent and allosteric regulation in signalling. Here we report the orthologous but cAMP-independent PKA of the protozoan Trypanosoma and identify 7-deaza-nucleosides as potent activators (E...

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Publicado no:Nat Commun
Main Authors: Bachmaier, Sabine, Volpato Santos, Yuri, Kramer, Susanne, Githure, George Boniface, Klöckner, Thomas, Pepperl, Julia, Baums, Cordula, Schenk, Robin, Schwede, Frank, Genieser, Hans-Gottfried, Dupuy, Jean-William, Forné, Ignasi, Imhof, Axel, Basquin, Jerôme, Lorentzen, Esben, Boshart, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440977/
https://ncbi.nlm.nih.gov/pubmed/30926779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09338-z
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