A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma

Purpose This first-in-human study evaluated SGN-CD70A, an antibody-drug conjugate (ADC) directed against the integral plasma membrane protein CD70 and linked to a pyrrolobenzodiazepine (PBD) dimer, in patients with relapsed or refractory (R/R) CD70-positive non-Hodgkin lymphoma (NHL) including diffu...

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Udgivet i:Invest New Drugs
Main Authors: Phillips, Tycel, Barr, Paul M., Park, Steven I., Kolibaba, Kathryn, Caimi, Paolo F., Chhabra, Saurabh, Kingsley, Edwin C., Boyd, Thomas, Chen, Robert, Carret, Anne-Sophie, Gartner, Elaina M., Li, Hong, Yu, Cindy, Smith, David C.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2018
Fag:
Phase I Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440937/
https://ncbi.nlm.nih.gov/pubmed/30132271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-018-0655-0
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