Crosstalk between tumor cells and lymphocytes modulates heparanase expression

BACKGROUND: Heparanase (HPSE) is an endo-beta-glucuronidase that degrades heparan sulfate (HS) chains on proteoglycans. The oligosaccharides generated by HPSE promote angiogenesis, tumor growth and metastasis. Heparanase-2 (HPSE2), a close homolog of HPSE, does not exhibit catalytic activity. Previo...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Transl Med
Auteurs principaux: Theodoro, Thérèse Rachell, Matos, Leandro Luongo, Cavalheiro, Renan Pelluzzi, Justo, Giselle Zenker, Nader, Helena Bonciani, Pinhal, Maria Aparecida Silva
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6439996/
https://ncbi.nlm.nih.gov/pubmed/30922347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1853-z
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