Crosstalk between tumor cells and lymphocytes modulates heparanase expression

BACKGROUND: Heparanase (HPSE) is an endo-beta-glucuronidase that degrades heparan sulfate (HS) chains on proteoglycans. The oligosaccharides generated by HPSE promote angiogenesis, tumor growth and metastasis. Heparanase-2 (HPSE2), a close homolog of HPSE, does not exhibit catalytic activity. Previo...

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Detalles Bibliográficos
Publicado en:J Transl Med
Main Authors: Theodoro, Thérèse Rachell, Matos, Leandro Luongo, Cavalheiro, Renan Pelluzzi, Justo, Giselle Zenker, Nader, Helena Bonciani, Pinhal, Maria Aparecida Silva
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6439996/
https://ncbi.nlm.nih.gov/pubmed/30922347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1853-z
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