Combination immunotherapy with IL-4 Pseudomonas exotoxin and IFN-α and IFN-γ mediate antitumor effects in vitro and in a mouse model of human ovarian cancer

AIM: We have shown that IL-4 fused to Pseudomonas exotoxin (IL-4-PE) is cytotoxic to ovarian cancer cell lines. The antineoplastic properties of IFN-α, IFN-γ and IL-4-PE have been studied and showed some promise in the clinical trials. Here, we investigated whether the combination of IL-4-PE, IFN-α...

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Detalhes bibliográficos
Publicado no:Immunotherapy
Main Authors: Green, Daniel S, Husain, Syed R, Johnson, Chase L, Sato, Yuki, Han, Jing, Joshi, Bharat, Hewitt, Stephen M, Puri, Raj K, Zoon, Kathryn C
Formato: Artigo
Idioma:Inglês
Publicado em: Future Medicine Ltd 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6439502/
https://ncbi.nlm.nih.gov/pubmed/30860437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/imt-2018-0158
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