Delayed remission following sequential infusion of humanized CD19- and CD22-modified CAR-T cells in a patient with relapsed/refractory acute lymphoblastic leukemia and prior exposure to murine-derived CD19-directed CAR-T cells

BACKGROUND: CD19-modified CAR-T cells greatly influence responses in patients with relapsed/refractory acute lymphoblastic leukemia (ALL). However, recurrence remains a challenge, and reinfusion of CAR-T cells is not always effective. Sequential infusion of humanized CD19-modified and CD22-modified...

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Vydáno v:Onco Targets Ther
Hlavní autoři: Yang, Fei, Zhang, Jian, Zhang, Xinyou, Tian, Mengli, Wang, Jingjing, Kang, Liqing, Qiu, Huiying, Wu, Depei
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438143/
https://ncbi.nlm.nih.gov/pubmed/30988623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S189103
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