Progressive Increase of Inflammatory CXCR4 and TNF-Alpha in the Dorsal Root Ganglia and Spinal Cord Maintains Peripheral and Central Sensitization to Diabetic Neuropathic Pain in Rats

Diabetic neuropathic pain (DNP) is a common and serious complication of diabetic patients. The pathogenesis of DNP is largely unclear. The proinflammation proteins, CXCR4, and TNF-α play critical roles in the development of pain, while their relative roles in the development of DNP and especially it...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Mediators Inflamm
Autori principali: Zhu, Dan, Fan, Tingting, Huo, Xinyue, Cui, Jian, Cheung, Chi Wai, Xia, Zhengyuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2019
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437743/
https://ncbi.nlm.nih.gov/pubmed/31001066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/4856156
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