SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade

Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 i...

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Publicado en:Acta Pharm Sin B
Autores principales: Zhao, Mingxia, Guo, Wenjie, Wu, Yuanyuan, Yang, Chenxi, Zhong, Liang, Deng, Guoliang, Zhu, Yuyu, Liu, Wen, Gu, Yanhong, Lu, Yin, Kong, Lingdong, Meng, Xiangbao, Xu, Qiang, Sun, Yang
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
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Original article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437555/
https://ncbi.nlm.nih.gov/pubmed/30972278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2018.08.009
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