Impact of Preexisting Hepatitis C Virus Genotype 6 NS3, NS5A, and NS5B Polymorphisms on the In Vitro Potency of Direct-Acting Antiviral Agents

HCV genotype 6 (GT-6) is found predominantly in East and Southeast Asia. Clinical studies have focused on patients infected with hepatitis C virus (HCV) GT-6a, where high sustained virologic response (SVR) rates to direct-acting antivirals (DAAs) have been achieved. However, GT-6 is highly diverse,...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: McPhee, Fiona, Ueland, Joseph, Vellucci, Vincent, Bowden, Scott, Sievert, William, Zhou, Nannan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437522/
https://ncbi.nlm.nih.gov/pubmed/30718256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02205-18
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