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Viability Screen of LOPAC(1280) Reveals Tyrosine Kinase Inhibitor Tyrphostin A9 as a Novel Partner Drug for Artesunate Combinations To Target the Plasmodium falciparum Ring Stage

The emergence of artemisinin-resistant Plasmodium falciparum poses a major threat to current frontline artemisinin combination therapies. Artemisinin resistance is widely associated with mutations in the P. falciparum Kelch13 (PfKelch13) propeller region, leading to delayed parasite clearance and in...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Tong, Jie Xin, Ang, Sarah E. L., Tan, Esther H. N., Tan, Kevin S. W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437515/
https://ncbi.nlm.nih.gov/pubmed/30718250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02389-18
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