Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing

A critical gap in tuberculosis (TB) treatment is detection of emergent drug resistance. We hypothesized that advanced phenotyping with whole-genome sequencing (WGS) will detect low-frequency Mycobacterium tuberculosis drug resistance. We assessed a reporter mycobacteriophage (Φ(2)GFP10) in vitro to...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: O’Donnell, Max R., Larsen, Michelle H., Brown, Tyler S., Jain, Paras, Munsamy, Vanisha, Wolf, Allison, Uccellini, Lorenzo, Karim, Farina, de Oliveira, Tulio, Mathema, Barun, Jacobs, William R., Pym, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Susceptibility
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437479/
https://ncbi.nlm.nih.gov/pubmed/30670422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01834-18
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