The protein phosphatase isoform PP1γ1 substitutes for PP1γ2 to support spermatogenesis but not normal sperm function and fertility

Four isoforms of serine/threonine phosphatase type I, PP1α, PP1β, PP1γ1, and PP1γ2, are derived from three genes. The PP1γ1 and PP1γ2 isoforms are alternately spliced transcripts of the protein phosphatase 1 catalytic subunit gamma gene (Ppp1cc). While PP1γ1 is ubiquitous in somatic cells, PP1γ2 is...

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Vydáno v:Biol Reprod
Hlavní autoři: Dudiki, Tejasvi, Joudeh, Nidaa, Sinha, Nilam, Goswami, Suranjana, Eisa, Alaa, Kline, Douglas, Vijayaraghavan, Srinivasan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437266/
https://ncbi.nlm.nih.gov/pubmed/30379985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioy225
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