Parent of origin genetic effects on methylation in humans are common and influence complex trait variation

Parent-of-origin effects (POE) exist when there is differential expression of alleles inherited from the two parents. A genome-wide scan for POE on DNA methylation at 639,238 CpGs in 5,101 individuals identifies 733 independent methylation CpGs potentially influenced by POE at a false discovery rate...

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Pubblicato in:Nat Commun
Autori principali: Zeng, Yanni, Amador, Carmen, Xia, Charley, Marioni, Riccardo, Sproul, Duncan, Walker, Rosie M., Morris, Stewart W., Bretherick, Andrew, Canela-Xandri, Oriol, Boutin, Thibaud S., Clark, David W., Campbell, Archie, Rawlik, Konrad, Hayward, Caroline, Nagy, Reka, Tenesa, Albert, Porteous, David J., Wilson, James F., Deary, Ian J., Evans, Kathryn L., McIntosh, Andrew M., Navarro, Pau, Haley, Chris S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437195/
https://ncbi.nlm.nih.gov/pubmed/30918249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09301-y
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