Extensive Ethnic Variation and Linkage Disequilibrium at the FCGR2/3 Locus: Different Genetic Associations Revealed in Kawasaki Disease

The human Fc-gamma receptors (FcγRs) link adaptive and innate immunity by binding immunoglobulin G (IgG). All human low-affinity FcγRs are encoded by the FCGR2/3 locus containing functional single nucleotide polymorphisms (SNPs) and gene copy number variants. This locus is notoriously difficult to g...

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Publicado en:Front Immunol
Autores principales: Nagelkerke, Sietse Q., Tacke, Carline E., Breunis, Willemijn B., Tanck, Michael W. T., Geissler, Judy, Png, Eileen, Hoang, Long T., van der Heijden, Joris, Naim, Ahmad N. M., Yeung, Rae S. M., Levin, Michael L., Wright, Victoria J., Burgner, David P., Ponsonby, Anne-Louise, Ellis, Justine A., Cimaz, Rolando, Shimizu, Chisato, Burns, Jane C., Fijnvandraat, Karin, van der Schoot, C. Ellen, van den Berg, Timo K., de Boer, Martin, Davila, Sonia, Hibberd, Martin L., Kuijpers, Taco W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437109/
https://ncbi.nlm.nih.gov/pubmed/30949161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00185
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