Extensive Ethnic Variation and Linkage Disequilibrium at the FCGR2/3 Locus: Different Genetic Associations Revealed in Kawasaki Disease

The human Fc-gamma receptors (FcγRs) link adaptive and innate immunity by binding immunoglobulin G (IgG). All human low-affinity FcγRs are encoded by the FCGR2/3 locus containing functional single nucleotide polymorphisms (SNPs) and gene copy number variants. This locus is notoriously difficult to g...

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Publicado no:Front Immunol
Main Authors: Nagelkerke, Sietse Q., Tacke, Carline E., Breunis, Willemijn B., Tanck, Michael W. T., Geissler, Judy, Png, Eileen, Hoang, Long T., van der Heijden, Joris, Naim, Ahmad N. M., Yeung, Rae S. M., Levin, Michael L., Wright, Victoria J., Burgner, David P., Ponsonby, Anne-Louise, Ellis, Justine A., Cimaz, Rolando, Shimizu, Chisato, Burns, Jane C., Fijnvandraat, Karin, van der Schoot, C. Ellen, van den Berg, Timo K., de Boer, Martin, Davila, Sonia, Hibberd, Martin L., Kuijpers, Taco W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437109/
https://ncbi.nlm.nih.gov/pubmed/30949161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00185
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