Reduced display of conformational epitopes in the N-terminal truncated GAD65 isoform: relevance for people with stiff person syndrome or DQ8/8-positive Type 1 diabetes mellitus

AIMS: To investigate whether the N-terminal truncated glutamic acid decarboxylase 65 (GAD65) isoform is as well recognized by people with stiff person syndrome as it is by people with Type 1 diabetes, and whether conformational GAD65 antibody epitopes are displayed properly by the isoform. METHODS:...

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Gepubliceerd in:Diabet Med
Hoofdauteurs: Hampe, C. S., Radtke, J. R., Wester, A., Carlsson, A., Cedervall, E., Jönsson, B., Ivarsson, S. A., Elding Larsson, H., Larsson, K., Lindberg, B., Neiderud, J., Rolandsson, O., Lernmark, Å.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437014/
https://ncbi.nlm.nih.gov/pubmed/30264481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dme.13827
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