Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: results from two prospective cohorts and CALGB 89803 (Alliance) trial

BACKGROUND: Prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase-2, COX-2)-prostaglandin E(2) (PGE(2)) pathway promotes tumour progression. Considering evidence suggesting increased PGE(2) synthesis by BRAF mutation in tumour cells, we hypothesised that the association of tumour PTGS2 (COX-2...

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Vydáno v:Eur J Cancer
Hlavní autoři: Kosumi, Keisuke, Hamada, Tsuyoshi, Zhang, Sui, Liu, Li, da Silva, Annacarolina, Koh, Hideo, Twombly, Tyler S., Mima, Kosuke, Morikawa, Teppei, Song, Mingyang, Nowak, Jonathan A., Nishihara, Reiko, Saltz, Leonard B., Niedzwiecki, Donna, Ou, Fang-Shu, Zemla, Tyler, Mayer, Robert J., Baba, Hideo, Ng, Kimmie, Giannakis, Marios, Zhang, Xuehong, Wu, Kana, Giovannucci, Edward L., Chan, Andrew T., Fuchs, Charles S., Meyerhardt, Jeffrey A., Ogino, Shuji
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436990/
https://ncbi.nlm.nih.gov/pubmed/30826660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2019.01.022
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