Comparative Epigenomics Reveals that RNA Polymerase II Pausing and Chromatin Domain Organization Control Nematode piRNA Biogenesis

Piwi-interacting RNAs (piRNAs) are important for genome regulation across metazoans, but their biogenesis evolves rapidly. In Caenorhabditis elegans, piRNA loci are clustered within two 3-Mb regions on chromosome IV. Each piRNA locus possesses an upstream motif that recruits RNA polymerase II to pro...

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Vydáno v:Dev Cell
Hlavní autoři: Beltran, Toni, Barroso, Consuelo, Birkle, Timothy Y., Stevens, Lewis, Schwartz, Hillel T., Sternberg, Paul W., Fradin, Hélène, Gunsalus, Kristin, Piano, Fabio, Sharma, Garima, Cerrato, Chiara, Ahringer, Julie, Martínez-Pérez, Enrique, Blaxter, Mark, Sarkies, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436959/
https://ncbi.nlm.nih.gov/pubmed/30713076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.12.026
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