Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials

BACKGROUND: Although herpes simplex viruses (HSV) are a major target for vaccine development no vaccine is currently licensed. METHODS: A live attenuated HSV virus vaccine, VC2 was compared to a subunit HSV vaccine, glycoprotein D (gD2) administered with the adjuvant, MPL/Alum using the guinea pig m...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Bernstein, David I., Cardin, Rhonda D., Pullum, Derek A., Bravo, Fernando J., Kousoulas, Konstantin G., Dixon, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436793/
https://ncbi.nlm.nih.gov/pubmed/30917165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0213401
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