Ablation of the microRNA-17-92 cluster in neural stem cells diminishes adult hippocampal neurogenesis and cognitive function

Impairment of adult neurogenesis in the hippocampus causes cognitive deficits; however, the underlying molecular mechanisms have not been fully elucidated. microRNAs (miRNAs) regulate neural stem cell (NSC) function. With the use of a transgenic mouse line with conditional ablation of the miR-17-92...

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Udgivet i:FASEB J
Main Authors: Pan, Wan Long, Chopp, Michael, Fan, Baoyan, Zhang, Ruilan, Wang, Xinli, Hu, Jiani, Zhang, Xiao Ming, Zhang, Zheng Gang, Liu, Xian Shuang
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436659/
https://ncbi.nlm.nih.gov/pubmed/30668139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801019R
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