In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors

An in silico screen of 350,000 commercially available compounds was conducted with an unbiased approach to identify potential malaria inhibitors that bind to the Plasmodium falciparum protein kinase 5 (PfPK5) ATP-binding site. PfPK5 is a cyclin-dependent kinase-like protein with high sequence simila...

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Publicado en:ChemMedChem
Autores principales: Eubanks, Amber L., Perkins, Marisha M., Sylvester, Kayla, Ganley, Jack G., Posfai, Dora, Sanschargrin, Paul C., Hong, Jiyong, Sliz, Piotr, Derbyshire, Emily R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436633/
https://ncbi.nlm.nih.gov/pubmed/30328274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800625
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