P2RX7 Deletion in T Cells Promotes Autoimmune Arthritis by Unleashing the Tfh Cell Response

Rheumatoid arthritis (RA) is an autoimmune disease that affects ~1% of the world's population. B cells and autoantibodies play an important role in the pathogenesis of RA. The P2RX7 receptor is an ATP-gated cation channel and its activation results in the release of pro-inflammatory molecules....

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Felix, Krysta M., Teng, Fei, Bates, Nicholas A., Ma, Heqing, Jaimez, Ivan A., Sleiman, Kiah C., Tran, Nhan L., Wu, Hsin-Jung Joyce
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436202/
https://ncbi.nlm.nih.gov/pubmed/30949163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00411
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